DYNAMIC TRANSMURALITY: CARDIAC OPTICAL MAPPING REVEALS WAVES TRAVEL ACROSS TRANSMURAL ABLATION LINES

Autor:	Mark L. Spano, Jennifer Simonotto, William L. Ditto, Abraham Miliotis, Michael D. Furman, Thomas M. Beaver
Rok vydání:	2007
Předmět:	Physics Subthreshold conduction Applied Mathematics Acoustics medicine.medical_treatment Attenuation Voltage-sensitive dye Atrial fibrillation Cardiac Ablation Ablation medicine.disease Signal Modeling and Simulation Optical mapping medicine Engineering (miscellaneous)
Zdroj:	International Journal of Bifurcation and Chaos. 17:3229-3234
ISSN:	1793-6551 0218-1274
DOI:	10.1142/s0218127407018981
Popis:	Cardiac ablation is increasingly used to interdict the complex propagation of excitatory waves during atrial fibrillation. While such procedures are useful, they can often fail. Here we use fluorescence imaging to observe the electrical activity of an ablated porcine heart. We find that, while ablation lines do attenuate cardiac waves, the attenuation is incomplete. A remnant of the incident wave survives passage through the ablation barrier, albeit as a subthreshold signal. More importantly, we have found that these subthreshold signals may add constructively and thereby dynamically reduce the effective attenuation, an effect which we call "dynamic transmurality". We suspect this as a factor in the persistence of arrhythmia after ablative.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::28129cb4f35bfc9fe35c4e9454dc3560 https://doi.org/10.1142/s0218127407018981 Zobrazit plný text záznamu