Psychiatric epigenetics: a new focus for the new century

Autor:	A D Paterson, Fabio Macciardi, G R Sutherland, T J Crow, A. Petronis, Lynn E. DeLisi, A J Klar, Francis J. McMahon, Melvin G. McInnis, Irving I. Gottesman, David Skuse
Rok vydání:	2000
Předmět:	medicine.medical_specialty Biology Genome Cellular and Molecular Neuroscience Psychiatry and Mental health Developmental stage theories Embryology DNA methylation medicine Epigenetics Psychiatry Molecular Biology Gene Psychiatric genetics Epigenesis
Zdroj:	Molecular Psychiatry. 5:342-346
ISSN:	1476-5578 1359-4184
DOI:	10.1038/sj.mp.4000750
Popis:	Among a multitude of new developments, a symposium dedicated specifically to epigenetic developments in psychiatric and related research was organized at the 7th World Congress of Psychiatric Genetics. The scientific term ‘epigenetics’ originates from epigenesis, which was one of the first developmental theories in embryology. 1 According to epigenesis, complex organisms develop from undifferentiated cells, while the competing theory of preformation stated that embryos preexist in a smaller scale in the germ cells of animal and plants. 2 While the last half of the 20th century has brought the realization that genes determine development, epigenetics has become a more adequate term to describe modifications of the genome that account for a diversity of cellular phenotypes in cells carrying identical DNA sequences. A variety of epigenetic phenomena have been identified over the last few decades. 3 Significant progress was made in understanding the epigenetic mechanisms of de novo and maintenance DNA methylation, nuclear compartmentalization, and chromatin conformation. 4
Databáze:	OpenAIRE
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