17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

Autor:	Sangsu Bang, Hyosuk Cho, Se Hwa Yoo, Tae Jin Yang, Sun Wook Hwang
Rok vydání:	2012
Předmět:	Pharmacology TRPV3 HEK 293 cells Inflammation Cell biology chemistry.chemical_compound Transient receptor potential channel chemistry Freund's adjuvant Cell culture Capsaicin medicine medicine.symptom Ion channel
Zdroj:	British Journal of Pharmacology. 165:683-692
ISSN:	0007-1188
DOI:	10.1111/j.1476-5381.2011.01568.x
Popis:	BACKGROUND AND PURPOSE Transient receptor potential ion channel vanilloid 3 (TRPV3) is expressed in skin keratinocytes and plays an important role in thermal and chemical nociceptions in the periphery. The presence of TRPV3 inhibitors would improve our understanding of TRPV3 function and help to develop receptor-specific analgesics. However, little is known about physiological substances that specifically inhibit TRPV3 activity. Here, we investigated whether 17(R)-resolvin D1 (17R-RvD1), a naturally occurring pro-resolving lipid specifically affects TRPV3 activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::27e2ae2d175184efc3a2f0d53e334531 https://doi.org/10.1111/j.1476-5381.2011.01568.x Zobrazit plný text záznamu Plný text ve formátu PDF