Evaluation of apparent diffusion coefficient and MR volumetry as independent associative factors for extra-prostatic extension (EPE) in prostatic carcinoma
| Autor: | Trevor A. Flood, Mohamed El-Khodary, Jeffrey S. Quon, Wael Shabana, Nicola Schieda, Soufiane El Hallani, Christopher S. Lim, Shaheed W. Hakim, Rebecca E. Thornhill |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.diagnostic_test
Receiver operating characteristic business.industry Prostatectomy medicine.medical_treatment Rectal examination medicine.disease 030218 nuclear medicine & medical imaging body regions 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine.anatomical_structure Prostate 030220 oncology & carcinogenesis Biopsy Carcinoma medicine Effective diffusion coefficient Radiology Nuclear Medicine and imaging business Nuclear medicine |
| Zdroj: | Journal of Magnetic Resonance Imaging. 43:726-736 |
| ISSN: | 1053-1807 |
| Popis: | Background To assess mean apparent diffusion coefficient (ADC) and MR-derived tumor volume (Vt) as associative factors for extra-prostatic extension (EPE) in prostate cancer (PCa). Methods With institutional review board approval, 73 consecutive patients diagnosed with PCa at trans-rectal ultrasound biopsy underwent preoperative multi-parametric (T2W+DWI+DCE) 3 Tesla MRI before radical prostatectomy between 2012 and 2014; 52% (38/73) patients had EPE. Clinical parameters including: age, prostate serum antigen (PSA), digital rectal examination (DRE) and percentage positive cores (PPC) were recorded. Two blinded radiologists subjectively evaluated for EPE using PI-RADS with T2W-MRI. A third blinded radiologist recorded: mean ADC (mm(2) /s) of tumor and tumor volume on ADC and T2W (derived from planar volumetry). VtMAX (the largest volume on ADC or T2W) was documented. Multivariate and receiver operator characteristic analyses were performed. Results There were no significant differences in age, DRE, or Gleason score between groups (P = 0.52, 0.06, 0.61, 0.36). PSA approached significance being higher with EPE (12.9 ± 12.6 versus 8.2 ± 7.4; P = 0.06). PPC was higher with EPE (60.9 ± 21.9% versus 38.3 ± 21.6%; P 0.05) except PPC (P = 0.6) for the diagnosis EPE. Conclusion MR volumetry and percentage of positive core biopsies are associated with EPE; whereas, in this study, other clinical and MR parameters including mean ADC and subjective T2W-MR analysis were not useful for assessment of EPE. |
| Databáze: | OpenAIRE |
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