Comparison of Dextropropoxyphene and Paracetamol with Paracetamol After Third Molar Dental Extractions

Autor: Christopher J Doecke, Michael J. Sorich, George A Osborne, David A Jarvis, Jillian Sprigg, Pamela E. Macintyre
Rok vydání: 2004
Předmět:
Zdroj: Journal of Pharmacy Practice and Research. 34:22-25
ISSN: 1445-937X
Popis: Background: Single-dose studies comparing the analgesic efficacy of dextropropoxyphene and paracetamol with paracetamol have usually found equi-analgesic effect. Whether this phenomenon is also so after multiple doses is uncertain. Aim: To determine whether the dextropropoxyphene and paracetamol combination has any advantages over paracetamol when used in multiple doses to relieve acute pain. Method: A randomised, double-blinded, parallel, controlled trial with two study arms: dextropropoxyphene hydrochloride 65 mg and paracetamol 650 mg combination with paracetamol 1000 mg. For the first 5 days following third molar dental extraction, patients in both study arms recorded scores for analgesia, satisfaction, wellbeing, and selected adverse effects. Results: 119 patients provided data. There were no significant differences in analgesic efficacy, satisfaction or wellbeing between the two groups. Other than increased incidence of vomiting on the first day following surgery in the combination group, adverse effects were similar between the groups. Conclusion: These results suggest that when patients with acute pain are blinded to the analgesic treatment, the combination of dextropropoxyphene and paracetamol has little or no advantage over paracetamol, even when multiple doses are used.
Databáze: OpenAIRE
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