| Popis: |
Techniques to derive mice with very specific mutations in any cloned gene are an exciting new addition to a series of impressive neuroscience tools that can be used to explore the connections between molecules, cells, circuits and behaving brains. The ease with which new mutant variants are generated, with overlapping but importantly different properties, provides the opportunity to generate and test models integrating molecular, physiological and behavioral observations. As an illustration of the versatility of this new approach, we will summarize studies of a mouse mutant for the α isoform of the Ca2+/calmodulin kinase II gene. |
