Cardioprotective Activity of Telmisartan, Metformin and its Combination against Doxorubicin Induced Myocardial Infarction in Rat Model
| Autor: | P. Aruna, N. M. Gayathiri |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cardiotoxicity
Anthracycline Troponin T business.industry Pharmacology medicine.disease 030218 nuclear medicine & medical imaging Metformin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Lactate dehydrogenase medicine Pharmacology (medical) Doxorubicin Myocardial infarction Telmisartan business Pharmacology Toxicology and Pharmaceutics (miscellaneous) medicine.drug |
| Zdroj: | Research Journal of Pharmacy and Technology. 11:5293 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.5958/0974-360x.2018.00964.2 |
| Popis: | Objective: The present study was designed to investigate the cardioprotective activity of telmisartan, metformin and its combination against doxorubicin induced myocardial infarction in rat by biochemical analysis. Methods: The therapeutic usefulness of doxorubicin (DXR), an anthracycline antibiotic, is limited by its cardiotoxicity. The study was conducted in albino wister rats (n=24) by using doxorubicin as negative control. the test drug, telmisartan and metformin was given alone and in combination for 15 days orally, on 14th & 15th day doxorubicin(15mg/kg) was injected intraperitoneally after the drug admistration except the normal control group. Results: The biochemical parameters, Troponin T shown to be negative for drug treated groups and positive for doxorubicin group (negative control). lactate dehydrogenase and CK-MB decreased for drug treated group then the negative control. Conclusion: These results suggest that the telmisartan and metformin treatment provides a significant cardioprotecive protective effect against acute-doxorubicin induced myocardial infarction in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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