| Autor: |
F. Imamura, Daisuke Makiura, Y. Goda, Y. Hashiguchi, M. Mizuta, N. Sugimoto, S. Fujita, Shinya Ueda, S. Ozaki, M. Kawayama, M. Niimi, Kojiro Futagami, N. Matsubara, T. Tamaki, M. Fukushima, K. Hirokaga, Won Seog Kim, A. Koyama, K. Matsumoto, H. Kusumoto, Y. Yoshida, T. Sasatomi, H. Akamatsu, A. Ohtsu, I. Sasaki, X. Liu, T. Ura, Chandra P. Belani, H. Yamamoto, K. Watanabe, N. Hokamura, H. Fukushima, H. Nishizaki, K. Yonesaka, Noriaki Ohuchi, S. Takao, H.-J. Tsai, Dimitri Pchejetski, K. Sunami, H. Fujimoto, J. Zhang, H. Samura, Tomoko Oku, M. Mori, Eiji Oki, T. Yano, N. Yamamoto, J. Tsukada, Yasutaka Sukawa, Kazuyoshi Yanagihara, A. Goy, J. Inoue, Kazuto Nishio, Y-C Chang, L. Wang, N. Kotani, M. Inomata, T. Nishimura, C.-C. Lin, N. Aisu, R. Saura, M. Makino, Hideki Shimodaira, Y. Fujishima, Satoshi Watanabe, H. Tanaka, Akiko Hisamoto, Koichi Akashi, J. E. Jang, T. Nobuoka, Chihiro Makimura, Taichi Isobe, T. Takahashi, C. Morizane, S.-M. Chang, N. Takigawa, F. Lv, N. Katagami, A. Kumagai, Takahide Komori, Koichi Hirata, N. Okamoto, A. Makiyama, Y. Takahashi, Hideyuki Hayashi, S. Iwasa, J.-C. Lin, J. S. Kim, K. Eguchi, A. Yokoyama, H. Kunimoto, M. Inoue, L. Sauer, H. Ueno, M. Nakano, A.-H. Kwon, Kiyoshi Ando, H. Nishimura, M. Kaibori, S. Arita, K. Tauchi, Erina Hatashita, H. Yoshioka, Ikuo Sekine, S. Iida, S.-F. Lin, J. Cao, H. Horinouchi, S. Atagi, H. Harashima, Hironori Ishigami, H. Isobe, Yoshimitsu Kobayashi, Shinichi Nishina, M. Motonaga, Tokuzo Arao, M. Edagawa, Kazuo Shirouzu, Kei Kawana, A. Kitamura, Emiko Sakaida, T. Ozaki, H. Fukada, Hiromichi Ishiyama, A. Tsuya, Manabu Muto, K. Takizawa, Satoru Kitazono, H. Uemura, T. Nakagawa, S. Kondo, Naoto Takahashi, Hisato Kawakami, M. D. Galsky, Shigeki Ito, Yoshihiko Maehara, S. Negoro, H. Matsushita, M. Kashiwa-Motoyama, Yoshinori Imamura, Kunio Okamoto, T. Ecke, Miyako Takahashi, T. Matsuno, K. Itoh, K. Tanaka, Kazuo Tamura, Y. Suzuki, A. Iwashima, K. Katayama, Tsuyoshi Shirakawa, M. Ohtsu, Ryohei Sasaki, M. Hayashi, M. Egyed, M. Tateyama, M. Munakata, T. Nomizu, T. Muta, T. Terauchi, Shin Takahashi, Y. Kohjimoto, I. Kawase, L. Qiu, Nozomi Niitsu, Y. Nishida, Hironori Yamaguchi, T. Sawai, T. Nakajima, Takanori Ishida, Tatsuo Oyake, M. Nagase, T. Yoshinami, Y. Sakata, Chiaki Imai, M. Kitazono, W. K. Oh, H. Kataoka, Y. Kakechi, Y. Terasaki, T. Miyagishima, Akira Yamada, A. Ono, R. Konno, M. Higashiguchi, Y. Namba, Hiroshi Kagamu, Eiki Ichihara, H. Nakasa, T. Yagi, Y. Tamaki, T. Onoe, N. Sonoda, Kazuhiko Nakagawa, H. Yamana, M. Sasaki, Yoji Ishida, K. Kaira, S. Yokoyama, W. Li, M. Tanioka, Eishi Baba, Hitoshi Kusaba, H. Suzuki, Sung Yong Oh, N. M. Hahn, Tomoko Kataoka, M. Mikami, Chikatoshi Katada, Y. Narita, J. Leach, T. Uehara, K. Miura, S. Yamamoto, O. Kobayashi, Kentaro Yamanaka, Katsuyuki Kiura, S. Hua, H. Miyao, Y. Kodama, Isamu Okamoto, K. Mikami, T. Hirashima, E. Konno, Naoko Chayahara, Junta Tanaka, Chang Fang Chiu, Hironobu Minami, Tadashi Hasegawa, Atsuo Okamura, T. Okusaka, K.-I. Nishiyama, M. Satouchi, Y. Maekawa, T. Kato, Rei Ono, F. Hongo, Mamoru Watanabe, T. Miki, M. Ogura, Masato Komoda, S. Natsugoe, Yuichi Takiguchi, I. Iwanaga, Hiroshi Soeda, Y. Fujiwara, M. Endo, H. Yasui, S. Katano, Satoshi Yuki, K. Nagai, H. Tsukuda, Jun Koshio, I. Hara, J. Tomomatsu, M. Kudo, Kenichi Yoshimura, T. Esaki, Satoshi Morita, R. Udagawa, M. Nakamura, S. Miura, K. Iwata, W. Su, N. Nonomura, S. J. Kim, Y. Omori, T. Shukuya, S. Y. Hyun, H. Hara, Yasunori Emi, M. Nezu, S. Tanimura, Koji Wada, Y. H. Min, D. Y. Hwang, Yoshito Komatsu, S. Takaishi, Kazuhiko Kobayashi, Mayumi Ono, K. Sato, Yuka Kato, T. Mine, S. Egawa, J. Li, N. Matsumura, Y. Tsuji, Hiroyuki Hata, Hirohisa Yoshizawa, S. Sogabe, Y. Guo, D. Kuroda, Chih-Cheng Chen, T. Takano, X. Hong, Y. D. Kim, K. Oda, Shoji Tokunaga, Masahiro Nozawa, Takeshi Sugawara, T. Fukui, Y. Saito, T. Fukuda, Yasuhisa Shinomura, Y. Yamashita, T. Minami, H. Mukai, Y. Ito, Ayumu Hosokawa, Hiroshi Nakatsumi, Y. Ohoka, S. Matsuyama, H. Takase, T. Akimoto, M. Ishizaki, T. Nakamura, Masahiro Tabata, T. Shimada, K. Shitara, Kimiharu Uozumi, T. Shiroyama, A. Umeta, N. Akakura, T.-Y. Chen, Kiyoko Kuwata, S. Emoto, Y. Naito, O. Muto, Cheolwon Suh, H. Oda, S. Fujii, Kenichiro Kudo, H. Hino, N. Morishita, Hiromichi Matsuoka, Y. Adachi, K. Minato, W.-Y. Kao, K. Hatake, Kosuke Ichikawa, Wataru Okamoto, S. H. Yoon, N. Wada, K. Uchida, U. Fujii, Ih-Jen Su, E. Vandendries, H. Ootsuka, Mitsuaki Tatsumi, K. Hatanaka, K. Matsui, M. Saijo, Fumihiko Fujita, W.-L. Hwang, Y. Negoro, M. Asanabe, Aya Kita, Hideo Baba, H. C. Chung, H. Igaki, J. Hashimoto, Yohei Funakoshi, Ukihide Tateishi, Masanori Toyoda, T. Feldman, Y. Kimura, T. Kondo, Yoshito Akagi, T. Kojima, A. Bamias, D. Takahari, Katsuyuki Hotta, K. Tobinai, K. Yamazaki, A. Volkert, T. Miyake, Hiroharu Yamashita, H. Iishi, Kazunori Murai, Y. Hata, M. Ri, H. Tomioka, S. Kato, M. Fukuoka, Y. Nakamura, Naomi Kiyota, Yee Soo Chae, T. Kimura, N. Gondo, Hiroshi Saeki, G. Sonpavde, H. S. Eom, K. Tane, Yasuo Ohashi, Yasuyuki Kawamoto, T. Beppu, T. Naito, M. Iwasaku, T. Ueda, R. Nakatake, Y. Umeyama, Takayasu Kurata, H. Kenmotsu, Hironori Ashinuma, Y. Miura, Ken-ichi Nibu, Y. Ogata, Toshihiro Miyamoto, N. Uike, K. Muro, S. Goya, Yasushi Takamatsu, Ichiei Narita, Chikashi Ishioka, T. Sueta, Satoshi Takeuchi, M.-C. Chang, Y. Iwanami, Yasuo Hamamoto, H. Kashihara, Yoshikazu Kotani, H. Daiko, Y. Kakugawa, J.-W. Cheong, T. Oochi, Joji Kitayama, K. Matsuo, M. Tamiya, Tzeon Jye Chiou, T. Sugiura, K. Kato, S. Krege, Masatomo Otsuka, A. Kitao, Y. Tanaka, Toru Mukohara, Masataka Taguri, Y. Hattori, T. Harada, Y. Hasegawa, S. Hoshino, K. Yoneyama, M. Ikeda, Shingo Tamura, H. Murakami, M. Kitada, K. Yanase, K. Nosho, C. S. Chim |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Annals of Oncology. 23:xi82 |
| ISSN: |
0923-7534 |
| DOI: |
10.1093/annonc/mds571 |
| Popis: |
Background The prognosis of gastric cancer with peritoneal metastasis is extremely poor. Neither systemic chemotherapy nor surgery alone prolongs survival of patients significantly. Methods Patients diagnosed with advanced gastric cancer underwent staging laparoscopy and received chemotherapy when peritoneal dissemination and/or cancer cells on peritoneal cytology were confirmed. The chemotherapy regimen consisted of S-1, weekly intravenous and intraperitoneal paclitaxel, which was verified in our phase II trial (Ann Oncol 2009). S-1 was administered at 80 mg/m2/day for 14 consecutive days, followed by 7 days rest. Paclitaxel was administered intravenously at 50 mg/m2 and intraperitoneally at 20 mg/m2 on days 1 and 8. Clinical response of chemotherapy was assessed by computed tomography, gastroendoscopy, peritoneal cytology and second-look laparoscopy. Radical gastrectomy was carried out when macroscopic curative resection was made achievable by chemotherapy. Chemotherapy was restarted after operation as soon as possible. Overall survival, relapse free survival, morbidity and mortality of gastrectomy were evaluated. Results Out of 100 patients with peritoneal metastasis who received chemotherapy, 60 patients underwent gastrectomy after response to chemotherapy, including 54 with macroscopic metastasis and 6 with positive peritoneal cytology only. A median of three courses were administered preoperatively (range 1–16). Total or distal gastrectomy with lymphnode dissection was carried out in 54 or 6 patients, respectively. The median survival time was 34.5 months. The median relapse-free survival was 16.7 months. The first site of relapse was the peritoneum in 24 patients and the other organ site in 17 patients. Postoperative complications included anastomotic leakage and pancreatic fistula in two patients each, which were healed conservatively. There were no treatment-related deaths. Conclusions Gastrectomy combined with S-1, intravenous and intraperitoneal paclitaxel is safe and active for gastric cancer patients with peritoneal metastasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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