ChemInform Abstract: Organocatalytic Aldol Reaction of Indole-3-carbaldehydes with Ketones: Synthesis of Chiral 3-Substituted Indoles

Autor: Li-Na Fu, Wei Wen, Yan Xiong, Biao Xu, Yu-Wan Liu, Lan-Xi Zhang, Qi-Xiang Guo, Shun-En Zhang
Rok vydání: 2013
Předmět:
Zdroj: ChemInform. 44
ISSN: 0931-7597
DOI: 10.1002/chin.201352113
Popis: An efficient aldol reaction of indole-3-carbaldehydes with ketones is described. O-TBS-protected l -threonine promoted the aldol addition of ketones to indole-3-carbaldehydes affording 3-indolylmethanols with good to excellent yields and diastereoselectivities, and excellent enantioselectivities.
Databáze: OpenAIRE