Modification of biologically active amides and amines with fluoro-containing heterocycles 11. Tetrahydrocarbazoles modified with 2-(5-fluoropyridin-3-yl)ethyl fragment

Autor:	A. Yu. Aksinenko, V. B. Sokolov, N. S. Nikolaeva, V. V. Grigor’ev, Sergey O. Bachurin, A. S. Kinzirsky
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Radioligand binding Fragment (computer graphics) Chemistry Michael reaction Organic chemistry Biological activity General Chemistry Fluoride Catalysis
Zdroj:	Russian Chemical Bulletin. 63:1137-1141
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-014-0561-3
Popis:	A method for the modification of tetrahydrocarbazoles with the 2-(5-fluoropyridin-3-yl)ethyl fragment was suggest, which consists in the reaction of 5-fluoro-3-vinylpyridine with tetrahydrocarbazoles under conditions of fluoride ion catalysis and leads to the earlier unknown 9-[2-(5-fluoropyridin-3-yl)ethyl]-2,3,4,9-tetrahydro-1H-carbazoles. Method of radioligand binding was used to study the influence of compounds synthesized on neuronal NMDA-receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2519c417468f4e05192f8601c59d39ef https://doi.org/10.1007/s11172-014-0561-3 Zobrazit plný text záznamu Full text from SpringerLink