Influence of Regenerative Capacity and Innervation on Oncogenesis in the Adult Frog (Rana pipiens)2

Autor:	R T Prehn, R P Custer, H C Outzen
Rok vydání:	1976
Předmět:	Denervation Cancer Research Pathology medicine.medical_specialty animal structures Regeneration (biology) Anatomy Biology medicine.disease_cause medicine.disease Tumor formation Rana medicine.anatomical_structure Oncology medicine Nerve supply Sarcoma Forelimb Carcinogenesis
Zdroj:	JNCI: Journal of the National Cancer Institute. 57:79-84
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/57.1.79
Popis:	Twenty-two sarcomas were induced in 19 adult frogs (Rana pipiens) treated with 3-methylcholanthrene pellets. Thirteen of these tumors arose first in a denervated forelimb, and only 2 arose first in normal or nerve-supplemented control forelimbs (P = 0.004). The remaining tumors developed either as a second tumor in a tumor-bearing frog or in hindlimbs. The critical role of innervation in regenerative capacity suggests that the predilection to tumor formation in the denervated limbs may have resulted from their lessened regenerative capacity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::251607184aa93f5f9d2140a4d7b082bf https://doi.org/10.1093/jnci/57.1.79 Zobrazit plný text záznamu