Ultra-rapid desensitization with rifampicin syrup

Autor: H. Bellali, Hafaoua Daghfous, F. Tritar, A. Ben Mansour, S. Ben Saad
Rok vydání: 2021
Předmět:
Zdroj: Revue Française d'Allergologie. 61:579-582
ISSN: 1877-0320
DOI: 10.1016/j.reval.2021.07.003
Popis: Hypersensitivity (HS) reactions to antituberculosis drugs are difficult to manage, notably since the advent of multiresistant tuberculosis. In patients with immediate HS to antituberculosis drugs, a rapid desensitization(DS) procedure may represent an interesting alternative. Study objectives Describe the procedure for rapid oral DS with rifampicin syrup/suspension and demonstrate its contribution to the management of tuberculosis (TB). Methods A cross sectional study including patients followed-up for tuberculosis in pulmonology C department of Abderrahman Mami Ariana hospital between 2003–2020. Patients with confirmed immediate HS were desensitized with a suspension of Rifampicin (100 mg/5 ml). Informed consent of patients or guardian was required. Results Ultrarapid DS with rifampicin syrup/suspensionwas performed in 14 patients (8 men, 6 women, mean age 32 ± 12.5 years). The mean times between initiation of the treatment, the last administration of the drug and onset ofthe reactions were 16.5 days (range:3–47 days) and 204 minutes (20–420 min)respectively. Most reactions were urticaria, pruritus and erythema. Severe anaphylaxis was reported in 2 cases and Quincke edema in 1 case. Nine patients (64.3%) were successfully desensitized. In 5 patients (35.7%), ultrarapid desensitization failed. Conclusion Reactions to rifampicin are diverse and unpredictable. The severity of the allergic reaction and the absence of other effective therapeutic alternatives are arguments in favor of drug desensitization. Despite the diversity of protocols reported in the literature, the results of desensitization are generally favorable, with a significant success rate.
Databáze: OpenAIRE
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