Synthesis of base-modified noraristeromycin derivatives and their inhibitory activity against human and Plasmodium falciparum recombinant S-adenosyl-l-homocysteine hydrolase

Autor:	Yukio Kitade, Toshihiro Miwa, Masayuki Nakanishi, Atushi Kozaki
Rok vydání:	2002
Předmět:	biology Chemistry Organic Chemistry Plasmodium falciparum biology.organism_classification Inhibitory postsynaptic potential Biochemistry nervous system diseases law.invention law S-adenosyl-L-homocysteine hydrolase parasitic diseases Drug Discovery Recombinant DNA Noraristeromycin cardiovascular diseases SAH Hydrolase
Zdroj:	Tetrahedron. 58:1271-1277
ISSN:	0040-4020
Popis:	Noraristeromycin derivatives possessing 2- or 8-position modified adenine or 8-aza-7-deazaadenine were synthesized, and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolases was investigated. Among these noraristeromycin derivatives, 2-aminonoraristeromycin selectively showed inhibitory activity against P. falciparum recombinant SAH hydrolase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::23f60def5afe14fe6049f09912e86d6e https://doi.org/10.1016/s0040-4020(01)01247-9 Zobrazit plný text záznamu Full Text from ScienceDirect