Electrochemical strategies for N-cyanation of secondary amines and α C-cyanation of tertiary amines under transition metal-free conditions

Autor:	Hu Cai, Jian Yin, Zhengjiang Fu, Guangguo Hao, Shengmei Guo, Yaping Fu, Tingting Zhong, Xuezheng Yi
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry Transition metal Functional group Environmental Chemistry Cyanation Electrochemistry Pollution Combinatorial chemistry Free Radical Process
Zdroj:	Green Chemistry. 23:9422-9427
ISSN:	1463-9270 1463-9262
DOI:	10.1039/d1gc02529e
Popis:	Transition metal-free electrochemical approaches for the N-cyanation of secondary amines and the α C-cyanation of tertiary amines have been well established, with products being obtained in moderate to good yields and with good functional group tolerance under ambient conditions. The synthetic application of the protocols has been highlighted through scale-up experiments in a galvanostatic mode. Preliminary mechanistic investigation has confirmed that TBAB played a critical role in N-cyanation transformation and has indicated that the transformation might proceed via a free radical process.
Databáze:	OpenAIRE
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