Creation of experimental models and study of the regeneratory potential of stem cells on these models
| Autor: | L. A. Gur’yantseva, E. V. Udut, L. A. Stavrova, Gol'dberg Ed, G. N. Zyuz’kov, T. V. Vetoshkina, V. V. Zhdanov, A. M. Dygai, N. V. Sotnikova, T. Yu. Khrichkova, T. I. Fomina, E. V. Simanina, T. Yu. Dubskaya, L. A. Ermolaeva |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Mesenchymal stem cell Clinical uses of mesenchymal stem cells Connective tissue Stimulation General Medicine Biology General Biochemistry Genetics and Molecular Biology Cell biology medicine.anatomical_structure medicine Bone marrow Progenitor cell Stem cell Fibroblast |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 143:1-8 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-007-0069-z |
| Popis: | Mobilization of mesenchymal stem cells and their more mature descendants, their differentiation into tissue-specific precursors, and the possibility of pharmacological stimulation of these processes were studied on models of some prevalent diseases. It was found that the development of any pathological process was associated with more or less pronounced activation of primitive and more differentiated mesenchymal precursors in the bone marrow, their mobilization into the peripheral blood, and increase in the content of regional precursors in organs exposed to pathogenic factors. Additional stimulation of stem cells with granulocytic colony-stimulating factor usually led to earlier or more pronounced increase in the content of mesenchymal progenitors in the bone marrow and peripheral blood. The content of tissue-specific and then fibroblast precursors in the regenerating organs also increased. This was paralleled by a decrease in the volume of developing connective tissue and degree of infiltration in these organs, while the percentage of tissue-specific structures increased. |
| Databáze: | OpenAIRE |
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