Fever induced by macrophage inflammatory protein-1β in the rat is independent of hypothalamic interleukin-1β or interleukin-6

Autor:	Francisco J López-Valpuesta, Francisco J. Miñano, Michael J. Dascombe, Antonio Fernández-Alonso, Khalid Benamar, M. Sancibrian, Eva Tavares
Rok vydání:	2000
Předmět:	biology Physiology medicine.medical_treatment Biochemistry Interleukin 1β Specific antibody Cytokine Immunology biology.protein medicine Macrophage Antibody General Agricultural and Biological Sciences Receptor Interleukin 6 Macrophage inflammatory protein Developmental Biology
Zdroj:	Journal of Thermal Biology. 25:5-10
ISSN:	0306-4565
DOI:	10.1016/s0306-4565(99)00036-4
Popis:	1. It has been proposed that macrophage inflammatory protein-1β (MIP-1β) induces fever via a cyclooxygenase-independent pathway. The roles of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in MIP-1β-induced fever were investigated in the rat, by using specific antibodies against these cytokines. 2. The intrahypothalamic injection of anti-MIP-1β, 15 min before the injection at the same site of MIP-1β significantly blocked the fever induced by this cytokine. 3. The pre-treatment with antibodies against IL-1β or IL-6 receptors, did not alter MIP-1β-induced fever. 4. These data support the hypothesis that MIP-1β produces fever via a parallel pathway, independent of the classical prostaglandin-dependent pathway adduced in the development of fever for IL-1β and IL-6.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::230fce8709bd2302e1cbeacb3ba1319b https://doi.org/10.1016/s0306-4565(99)00036-4 Zobrazit plný text záznamu Full Text from ScienceDirect