Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy
| Autor: | U. J. Spreng, Johan Raeder, Vegard Dahl |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
biology medicine.drug_class Visual analogue scale business.industry medicine.medical_treatment Analgesic Pregabalin General Medicine biology.organism_classification Anxiolytic Surgery Pacu Anesthesiology and Pain Medicine Anesthesia Discectomy medicine Anxiety General anaesthesia medicine.symptom business medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 55:571-576 |
| ISSN: | 0001-5172 |
| DOI: | 10.1111/j.1399-6576.2011.02410.x |
| Popis: | Background: Pregabalin acts as a membrane stabilizer and has both analgesic and anxiolytic effects. We hypothesized that one pre-operative dose of pregabalin would reduce pre-operative anxiety and post-operative pain in patients undergoing discectomy. Methods: We performed a randomized, placebo-controlled study of 150 mg pregabalin administered before lumbar discectomy in general anaesthesia. The primary endpoint was pain at rest [visual analogue scale (VAS)] 120 min after surgery. The secondary outcomes were morphine consumption, pre-operative anxiety (VAS) and the occurrence of side effects. Results: The VAS scores for pain at rest and morphine consumption were higher in the placebo group during the 4-h stay in the post-anaesthetic care unit (PACU), but did not differ significantly 24 h after surgery. Pain scores at 7 days were similar and there was no difference in the occurrence of side effects. Pre-operative anxiety was significantly lower in the pregabalin group (2.23±1.11 vs. 4.17±2.37, 95% confidence interval: 0.82–3.05, P=0.001) and there was a significant positive correlation between the pre-operative anxiety score and post-operative pain at 120 min in the pregabalin group. Conclusions: A single dose of pregabalin (150 mg) reduced post-operative pain at rest and morphine consumption during the PACU period after lumbar discectomy. Pre-operative anxiety was lower, without increased incidence of side effects. |
| Databáze: | OpenAIRE |
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