ChemInform Abstract: Stereoselective Synthesis of (.+-.)-Ireland Alcohol Using Titanium-Mediated (2,3)Wittig Rearrangement Product as a Starting Material

Autor:	Satoru Kuroda, Hiroaki Okamura, Tsutomu Katsuki, Satoru Ikegami, Masaru Yamaguchi
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Wittig reaction Organic chemistry chemistry.chemical_element Alcohol Stereoselectivity General Medicine 2 3-Wittig rearrangement Tirandamycin A Isopropyl Titanium
Zdroj:	ChemInform. 23
ISSN:	0931-7597
DOI:	10.1002/chin.199244290
Popis:	The synthesis of (±)-Ireland alcohol, a key intermediate for the synthesis of tirandamycin A, was achieved in a straightforward manner by using isopropyl (2R*, 3S*, 4E)-6-benzyloxy-2-hydroxy-3-methyl-4-hexenoate as a starting material, which was readily obtained by the [2,3]Wittig rearrangement of isopropyl [(E)-1-benzyloxymethyl-2-butenyloxy]acetate via its titanium enolate.
Databáze:	OpenAIRE
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