Sumo1-ylation of human spermatozoa and its relationship with semen quality

Autor:	L. Giuliano, Daniele Nosi, V. Sarli, Elisabetta Baldi, Paola Piomboni, Gianni Forti, Monica Muratori, Lara Tamburrino, Sara Marchiani, Loredana Gandini, Giuseppe Belmonte
Rok vydání:	2010
Předmět:	endocrine system medicine.diagnostic_test urogenital system Urology Endocrinology Diabetes and Metabolism Immunoelectron microscopy Motility Semen Semen analysis Biology Immunofluorescence Andrology Semen quality Reproductive Medicine medicine Spermatogenesis Sperm motility
Zdroj:	International Journal of Andrology. 34:581-593
ISSN:	0105-6263
DOI:	10.1111/j.1365-2605.2010.01118.x
Popis:	Summary Sumoylation is a post-translational modification involved in the regulation of several cell functions. Recent studies suggest its involvement in spermatogenesis, but occurrence and function of SUMO (small ubiquitin-like modifier) in mature spermatozoa remain unknown. We report the occurrence of several SUMO1-conjugated proteins, in a range of 20–85 kDa, in ejaculated spermatozoa. By cytofluorimetric analysis, we evaluated the percentage of SUMO1-positive spermatozoa in 58 subjects undergoing semen analysis in our laboratory and correlated the obtained values with semen parameters. We found that the percentage of SUMO1-positive spermatozoa was inversely correlated with total (r = −0.35, p
Databáze:	OpenAIRE
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