| Popis: |
Apathy is defined as the loss of motivation expressed as diminished behaviours, intellectual activity, and emotional feelings and display. Apathy is present in approximately one third of cross-sectional samples of patients with Parkinson’s disease (PD) and is usually associated with depression and/or dementia. Apathy is more frequent in late stages of PD and has been reported as a side effect of deep brain stimulation. A recent trial demonstrated that the D2/D3 agonist piribedil may improve apathy in PD, but more controlled studies are needed. |
