| Autor: |
Abubakar Abdulkadir, Eke S. Samuel, Otuu A. Chidiebere, Yamman-Usman Hadijah, Omalu C.J. Innocent, S.O. Abolarinwa |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Innovare Journal of Medical Sciences. :31-35 |
| ISSN: |
2321-4406 |
| DOI: |
10.22159/ijms.2021.v9i3.41268 |
| Popis: |
Objective: A cross-sectional study was carried out in a representative cohort of children in Minna aged 6 months–17 years to determine the correlation between immunoglobulin G (IgG) antibody responses to Plasmodium falciparum merozoite antigens. Methods: Plasma samples from 93 children were exposed to Enzyme-Linked Immunosorbent Assay for the measurement of IgG antibody production against P. falciparum. Results: There was a high seroprevalence of IgG antibody against P. falciparum antigens tested with 74.20%. The seroprevalence for the male category was quite higher as compared with that of the female category, though, analysis using Mann–Whitney U-test revealed IgG antibody response to P. falciparum infection in the male was significantly different as compared to the female category (p0.05). An evidence of more than 50% was found for the production of IgG antibody by sub-microscopic parasite. On the other hand, microscopically positive P. falciparum samples recorded more seroprevalence of 68.81% as against negative samples, though significant difference between the negative and positive P. falciparum infected samples and the production of IgG antibody was not observed (p>0.05). Conclusion: This study has demonstrated a boosting immune responses by sub-microscopic parasite and also suggests a strong relationship between production of IgG antibody and malaria transmission, rather than protective immunity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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