WIRION Embolic Protection System in Lower Extremity Arterial Interventions
| Autor: | Uri Rosenschein, Anthony Pucillo, J. Stephen Jenkins, Thomas Zeller, Thomas E. Davis, Dierk Scheinert, William A. Gray, Lawrence A. Garcia, Ehrin J. Armstrong, Herbert D. Aronow, Nicolas W. Shammas |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Perforation (oil well) 030204 cardiovascular system & hematology medicine.disease Interim analysis Thrombosis Surgery Atherectomy 03 medical and health sciences Pseudoaneurysm 0302 clinical medicine Embolism Amputation medicine Clinical endpoint 030212 general & internal medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | JACC: Cardiovascular Interventions. 11:1995-2003 |
| ISSN: | 1936-8798 |
| Popis: | Objectives The WISE LE (WIRION™ EPS in Lower Extremities Arteries) study was designed to assess the clinical performance of the WIRION Embolic Protection System (EPS) in subjects undergoing lower extremity atherectomy for the treatment of peripheral artery disease. Background Embolization is ubiquitous during endovascular procedures for lower extremity peripheral artery disease. Methods The WISE LE was a multicenter study, performed in the United States and Germany. The primary endpoint was freedom from major adverse events (MAEs) occurring within 30 days post-procedure and was compared with an objective performance goal derived from historical atherectomy trials. MAE was defined as a serious adverse event that resulted in death, acute myocardial infarction, thrombosis, pseudoaneurysm, dissection (grade C or greater), or clinical perforation at the filter location, clinically relevant distal embolism, unplanned amputation, or clinically driven target vessel revascularization. The study also included a histopathological analysis of debris captured by the filter during the procedures. Results The study protocol specified enrollment of 153 patients with the primary endpoint successfully met if 18 (12.0%) or fewer MAEs occurred. A pre-specified interim analysis performed after 103 patients revealed only 2 MAEs, and the study was stopped because it had met its pre-determined metric for success. Lesion deemed not accessible by the WIRION EPS occurred in 7 patients. Debris of 2-mm diameter were found in 98%, 22%, and 9% of patients, respectively. Conclusions The WIRION EPS is safe and noninferior to the pre-specified performance goal in capturing debris in the vast majority of patients and with the use of a broad range of atherectomy systems. |
| Databáze: | OpenAIRE |
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