In-house preparation of macroaggregated albumin (MAA) for 68Ga labeling and its comparison with commercially available MAA
| Autor: | Haladhar Dev Sarma, Usha Pandey, Ramu Ram, Akanksha Jain, Suresh Subramanian, Ashutosh Dash |
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| Rok vydání: | 2015 |
| Předmět: |
business.industry
Chemistry Health Toxicology and Mutagenesis Radiochemistry Public Health Environmental and Occupational Health Pet imaging Pollution 030218 nuclear medicine & medical imaging Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Nuclear Energy and Engineering 030220 oncology & carcinogenesis Spect imaging otorhinolaryngologic diseases Radiology Nuclear Medicine and imaging Macroaggregated albumin Leaching (metallurgy) Nuclear medicine business Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 308:817-824 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-015-4509-3 |
| Popis: | 99mTc labeled macroaggregated albumin (MAA) is used worldwide for SPECT imaging of lungs, using commercially available MAA kits. An attempt was made to indigenously prepare MAA for radiolabeling with 68Ga, for PET imaging. MAA particles (59.9 ± 18.1 µm) were successfully prepared in-house and radiolabeled with 68Ga. Retention of in-house synthesized 68Ga-MAA in lungs of Swiss mice (71.6 ± 2.1 %ID) was similar to that of 68Ga-MAA prepared using commercial kits (83.5 ± 2.3 %ID). In vivo Cherenkov luminescent imaging of in-house prepared 68Ga-MAA in Swiss mice at 15 min and 60 min p.i. showed maximum retention of activity in lungs and negligible leaching into liver. |
| Databáze: | OpenAIRE |
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