Prebiotic effect of native noncovalent arabinogalactan—flavonoid conjugates on bifidobacteria

Autor: P. A. Medvedeva, Yu. N. Kupriyanovich, Boris G. Sukhov, A. A. Pristavka, S. M. Popkova, Boris A. Trofimov, E. B. Rakova, Yu. P. Dzhioev, D. S. Selivanova, G. V. Yurinova, S. V. Kuznetsov, N. N. Pogodaeva
Rok vydání: 2014
Předmět:
Zdroj: Russian Chemical Bulletin. 63:2189-2194
ISSN: 1573-9171
1066-5285
DOI: 10.1007/s11172-014-0718-0
Popis: Arabinogalactan extracted from Siberian larch on an industrial scale was found to exist as noncovalent glycoconjugates with a group of wood extractive substances (their content in arabinogalactan is ~3%). The flavonoids dihydroquercetin (prevailing in extractive substances with a percentage of ~24%), aromadendrin, and quercetin were identified among the extractive substances. Flavonoid—arabinogalactan conjugates are readily soluble in water (unlike virtually insoluble free flavonoids) and exhibit highly effective antiradical properties directly in an aqueous solution (the hydrophilic ABTS+• model). Flavonoid—arabinogalactan conjugates, as well as arabinogalactan specially purified from flavonoids, can be used as an energy and carbon source for indigenous probiotic microbes: the polysaccharide is hydrolyzed by the enzymatic system of bifidobacterial β-glycosidases to form reducing sugars digested into organic acids. The growth and functional characteristics of bifidobacteria are influenced by the degree of urity of the polysaccharide. Thus, flavonoid—arabinogalactan conjugates retard the growth of bifidobacteria and the formation of organic acids, which can be attributed to the antimicrobial activity of flavonoids (antiradical disruption of physiological redox-signaling of microbial cells)
Databáze: OpenAIRE
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