In Vitro Effect of Multiple Antibiotic/Antimicrobial Residues on the Selection for Resistance in Bacteria

Autor:	Marietta Sue Brady, Stanley E Katz
Rok vydání:	1992
Předmět:	Pharmacology biology Resistance (ecology) Chemistry medicine.drug_class Antibiotics Antimicrobial biology.organism_classification In vitro Analytical Chemistry Microbiology medicine Environmental Chemistry Agronomy and Crop Science Bacteria Selection (genetic algorithm) Food Science
Zdroj:	Journal of AOAC INTERNATIONAL. 75:738-741
ISSN:	1944-7922 1060-3271
DOI:	10.1093/jaoac/75.4.738
Popis:	A method using a gram-positive and a gram-negative organism was used to investigate the selection for resistant populations after exposure to residue levels of 7 antibiotics and 1 antimicrobial. The organisms were exposed to individual compounds and combinations of 3 compounds for 14 days. The changes in minimum inhibitory concentration (MIC) of a panel of 8 antibiotics and 1 antimicrobial were used as the measure of resistance development/selection. For Staphylococcus aureus ATCC 9144, exposure to residue levels of oxytetracycline, tylosin, penicillin, and virginiamycin resulted in an increased MIC of the compound itself; most individual residues did not result in increased cross-resistance. With combinations of residues, 13 of 45 determinations resulted in significant increases in MIC. Enterobacter cloacae B520, which was much less sensitive to 4 of 9 markers, showed MIC increases only for tylosin and the combination of neomycin-sulfamethazine-oxytetracycline. The results indicate an interaction among residue levels of antibiotics in selection for resistance.
Databáze:	OpenAIRE
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