Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system
| Autor: | Yin Cheng Huang, Hung Yu Shih, Tu Hsueh Yeh, Han Fang Liu, Ming-Chang Chiang, Hao Yuan Chen, Yi-Chuan Cheng, Chien Ping Wang, Yen Che Hsieh |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Central nervous system Peroxisome proliferator-activated receptor biology.organism_classification Phenotype Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure chemistry medicine Signal transduction Receptor Zebrafish Neural development Function (biology) Developmental Biology |
| Zdroj: | Developmental Dynamics. 247:1264-1275 |
| ISSN: | 1058-8388 |
| Popis: | Background Many molecules and signaling pathways involved in neural development play a role in neurodegenerative diseases and brain tumor progression. Peroxisome proliferator-activated receptor (PPAR) proteins regulate the differentiation of tissues and the progression of many diseases. However, the role of these proteins in neural development is unclear. Results We examined the function of Pparα in the neural development of zebrafish. Two duplicate paralogs for mammalian PPARA/Ppara, namely pparaa and pparab, are present in the zebrafish genome. Both pparaa and pparab are expressed in the developing central nervous system in zebrafish embryos. Inhibiting the function of Pparα by using either the PPARα/Pparα antagonist GW6471 or pparaa or pparab truncated constructs produced identical phenotypes, which were sufficient to reduce the proliferation of neuronal and glial precursor cells without affecting the formation of neural progenitors. Conclusions We demonstrated that both Pparαa and Pparαb proteins are essential regulators of the proliferation of neuronal and glial precursors. This study provides a better understanding of the functions of PPARα/Pparα in neural development and further expands our knowledge of the potential role of PPARα/Pparα in neurological disorders and brain tumors. Developmental Dynamics 247:1264-1275, 2018. © 2018 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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