| Popis: |
Motor complications of Parkinson's disease (PD) have been reported to occur after a few years of treatment with levodopa (L-dopa). Morning akinesia is a delayed ON of the first L-dopa daily dose, occurring in almost 60% of patients on dopaminergic treatment. This is primarily a motor symptom, but has been recently recognized as being correlated with nonmotor fluctuations. Sleep disorders and gastrointestinal dysfunction might be the underly - ing mechanisms. Over the past 30 years, several pharmacological and nonpharmacological approaches have been investigated. |
