Significance of antibodies to cardiolipin in unselected patients with systemic lupus erythematosus: clinical and laboratory associations
| Autor: | E. Henkel, Helmuth Deicher, H. J. Lakomek, K. Lüthke, B. Liedvogel, J. R. Kalden, C. Sachse, K. Hartung, Hans-Hartmut Peter, M. Fricke |
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| Rok vydání: | 1995 |
| Předmět: |
Systemic disease
Lupus erythematosus biology business.industry Immunology medicine.disease Connective tissue disease Rheumatology immune system diseases Antiphospholipid syndrome Immunopathology medicine biology.protein Immunology and Allergy Anti-cardiolipin antibodies cardiovascular diseases Antibody medicine.symptom skin and connective tissue diseases business Livedo reticularis |
| Zdroj: | Rheumatology International. 15:23-29 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/bf00286765 |
| Popis: | In a multicentre study anticardiolipin antibodies of the IgG and IgM isotypes were measured by a solid phase enzyme immunoassay in 368 patients with systemic lupus erythematosus (SLE) who were not selected on the basis of features of antiphospholipid syndrome. Clinical and laboratory associations of increased levels of anticardiolipin antibodies were evaluated. IgG and IgM antibodies to cardiolipin were documented in 224 (60.9%) and 128 (34.8%) patients, respectively. Regarding the symptoms of antiphospholipid syndrome, elevated amounts of anticardiolipin IgG were significantly associated with spontaneous abortion (P |
| Databáze: | OpenAIRE |
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