Role of hepatic microsomal oxidation in regulation of monoamine oxidase mediated processes in rat brain (727.1)
| Autor: | Vadim Tseylikman, Eugenia Manukhina, H Downey, Olga Tseylikman, Denis Kozochkin, Roman Deev, Mariya Misharina, Mariya Komelkova |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
biology Cytochrome Chemistry Monoamine oxidase Cytochrome P450 Biochemistry Lipid peroxidation chemistry.chemical_compound Hexobarbital Endocrinology Internal medicine Genetics biology.protein medicine Microsome Serotonin Monoamine oxidase B Molecular Biology Biotechnology medicine.drug |
| Zdroj: | The FASEB Journal. 28 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.28.1_supplement.727.1 |
| Popis: | Monoamine oxidase (MAO) plays a key role in metabolism of biogenic amines and serves as a marker of alcoholism and depressive disorders. Various isoforms of cytochrome This study was focused on the relationship between MAO activity and hepatic content of cytochrome P450 which reflects the state of microsomal oxidation. Methods. For vital integrative evaluation of hepatic microsomal oxidation in rats, the hexobarbital sleep test was used. Content of cytochrome P450 was measured in hepatic microsomes. Activities of MAO-A and MAO-B were measured in the whole brain and brain structures. Content of serotonin, a MAO substrate was measured in the brain and plasma. Intensity of oxidative stress was evaluated by measuring lipid peroxidation products and carbonylated proteins in brain. Results. Rats with short hexibarbital sleep time (SHST) had higher content of microsomal cytochrome P450 than rats with long hexobarbital sleep time (LHST). Whole brain MAO-A and MAO-B activities, serotonin and carbonylated protein l... |
| Databáze: | OpenAIRE |
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