Clinical features of hepatitis B e-antigen positive chronic hepatitis B patients co-existing precore and/or basal core promoter mutations

Autor:	En-Qiang Chen, Hong Tang, Xiaoqiong Tang, Lang Bai, Li-Bo Yan, Xia Zhu, Lingyao Du, Qing-Bo Zhang
Rok vydání:	2018
Předmět:	0301 basic medicine Hepatitis b e antigen business.industry virus diseases Promoter Virology digestive system diseases 03 medical and health sciences Basal (phylogenetics) 030104 developmental biology 0302 clinical medicine Chronic hepatitis Medicine 030211 gastroenterology & hepatology business
Zdroj:	Future Virology. 13:687-695
ISSN:	1746-0808 1746-0794
Popis:	Aim: Characterize the clinical features of treatment-naive hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients harboring either precore (PC) or basal core promoter (BCP; PC/BCP) mutations. Methods: Alanine aminotransferase, HBsAg, HBV-DNA, HBV genotypes, PC/BCP mutations and liver stiffness measurement were assessed for 186 treatment-naive HBeAg-positive CHB patients. Results: PC/BCP mutations were found in 40.31% of the treatment-naive HBeAg-positive CHB patients. Patients with PC/BCP mutations showed significantly higher alanine aminotransferase and liver stiffness measurement levels. The serum HBsAg and HBV DNA levels in patients with BCP mutations were significantly lower than those in patients with wild-type virus. PC/BCP mutations were more prevalent in patients in immune clearance phase than those in immune tolerance phase. Conclusion: The emergences of PC/BCP mutations possibly indicate that HBeAg positive patients are experiencing the phase of immune clearance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1dbc1c453afe44ba51f5a54f89ebb26f https://doi.org/10.2217/fvl-2018-0091 Zobrazit plný text záznamu