Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
| Autor: | James L Kennedy, Heather A. Baitz, G. William MacEwan, Daniel J. Müller, Donna J. Lang, Ivan J. Torres, William G. Honer, Thomas S. Ehmann, Kristina M. Gicas, Alasdair M. Barr, Fidel Vila-Rodriguez, Allen E. Thornton, Geoff N Smith, Lili C. Kopala |
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| Rok vydání: | 2017 |
| Předmět: |
Psychosis
California Verbal Learning Test Intelligence quotient Recall medicine.diagnostic_test business.industry Repeated measures design Neuropsychological test medicine.disease 3. Good health 030227 psychiatry 03 medical and health sciences 0302 clinical medicine Schizophrenia Medicine Verbal memory business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Neuropsychiatric Disease and Treatment. 13:2945-2953 |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s150488 |
| Popis: | Background Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-e4 is the main genetic risk factor for late-onset Alzheimer’s disease. Our primary goal was to ascertain whether APOE-e4 status had a pleiotropic effect in early stages of the illness. Participants and methods A total of 86 first-episode psychosis (FEP) outpatients and 39 healthy volunteers were recruited. Demographic and clinical data, APOE genotyping, and a neuropsychological test battery including the California Verbal Learning Test – second edition (CVLT-II) were administered and assessed at study entry and at 1-year follow-up. Data were analyzed using mixed-model repeated measures, where the dependent variable was verbal memory indexed by California Verbal Learning Test (CVLT) Trials 1–5 total recall score. Results FEP-APOE-e4 carriers and FEP-APOE-e4 noncarriers had similar symptom severity, clinical outcomes, premorbid and current intelligence quotient, and exposure to antipsychotics. There was a main effect of group on CVLT 1–5 (FEP =43.30 vs control =58.25; F[1, 119.7]=42.97; P |
| Databáze: | OpenAIRE |
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