PENGARUH RESTRIKSI KALORI TERHADAP KADAR HIDROGEN PEROKSIDA DAN KADAR GLUKOSA DARAH PADA TIKUS TUA
| Autor: | Kusworini Handono, Anik Widijanti, Putu Moda Arsana, E. Harianja |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Insulin medicine.medical_treatment Calorie restriction Normal level medicine.disease One-way analysis of variance chemistry.chemical_compound Endocrinology Least significant difference Insulin resistance chemistry Internal medicine Hyperinsulinemia General Earth and Planetary Sciences Medicine business Hydrogen peroxide General Environmental Science |
| Zdroj: | INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 14:24-27 |
| ISSN: | 2477-4685 0854-4263 |
| DOI: | 10.24293/ijcpml.v14i1.921 |
| Popis: | Aging is a syndrome of progressive, universal and irreversible alterations. Endocrinology alterations in aging consist of insulin resistance, hyperinsulinemia, increase of hydrogen peroxide and glucose blood level. At the beginning of aging process the Pancreaticcells produce more insulin in order is keep blood glucose within normal level. But the persistent of hyperglycemia condition caused the pancreatic-cells unable to produce adequate insulin due to internal factors or external factors. As this condition progress, would be disturbed fasting and post-prandial blood glucose (hyperglicemia). Besides insulin resistance, free radicals also increased as a consequence of failure compensation of cells in the body. The aim of this study is to determine that intermittent and daily calorie restriction in old male Wistar rats can reduce serum hydrogen peroxide, and blood glucose level. The method of this study was an experimental study with post-test control group design. Twenty four male Wistar rats about 12 months old, were divided into four equal groups and each group contain six rats: (i) ad libitum fed (control), (ii) 2-1 intermittent with 2 days fed and 1 day fast, (iii) 1-1 intermittent with 1 day fed and 1 day fast, and (iv) 40% continuous calorie restriction every day. Independent variable in this study was calorie intake and body weight. Dependent variables were hydrogen peroxide level and. Blood glucose level. The difference of each group was analyzed with one way ANOVA and the least significant difference was analyzed by the use post hoc tests, using p < 0.05. The result of this study for hydrogen peroxide and blood glucose level in control group with experimental groups were p 0.000 and p 0.001. There was positive correlation between hydrogen peroxide level and blood glucose level r 0.791. We conclude that calorie restriction decrease hydrogen peroxide level and as well as regulating of blood glucose level. The best one of this method is 40% calorie restriction. |
| Databáze: | OpenAIRE |
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