Autophagy in Dementias
| Autor: | Christine Lund Kragh, Eliezer Masliah, Tony Wyss-Corey, Kiren Ubhi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Alpha-synuclein
Parkinson's disease Dementia with Lewy bodies General Neuroscience Autophagy medicine.disease Pathology and Forensic Medicine chemistry.chemical_compound chemistry mental disorders medicine Dementia Neurology (clinical) Vascular dementia Psychology Neuroscience Neurocognitive Frontotemporal dementia |
| Zdroj: | Brain Pathology. 22:99-109 |
| ISSN: | 1015-6305 |
| Popis: | Dementias are a varied group of disorders typically associated with memory loss, impaired judgment and/or language and by symptoms affecting other cognitive and social abilities to a degree that interferes with daily functioning. Alzheimer’s disease (AD) is the most common cause of a progressive dementia, followed by dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VaD) and HIV associated neurocognitive disorders (HAND). The pathogenesis of this group of disorders has been linked to the abnormal accumulation of proteins in the brains of affected individuals, which in turn has been related to deficits in protein clearance. Autophagy is a key cellular protein clearance pathway with proteolytic cleavage and degradation via the ubiquitin-proteasome pathway representing another important clearance mechanism. Alterations in the levels of autophagy and the proteins associated with the autophagocytic pathway have been reported in various types of dementias. This review will examine recent literature across these disorders and highlight a common theme of altered autophagy across the spectrum of the dementias. |
| Databáze: | OpenAIRE |
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