| Autor: |
Palmer H. Futcher, Kendall Emerson, Lee E. Farr |
| Rok vydání: |
1940 |
| Předmět: |
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| Zdroj: |
The Journal of Pediatrics. 17:595-614 |
| ISSN: |
0022-3476 |
| DOI: |
10.1016/s0022-3476(40)80131-5 |
| Popis: |
Summary 1. Nitrogen balance studies of ten weeks' duration have been reported on four children with the nephrotic syndrome. 2. Replacement of 33 to 57 per cent of dietary protein nitrogen with nitrogen furnished by casein hydrolysate given intravenously increased slightly the efficiency of nitrogen utilization in these patients and within this range of substitution indicated that casein hydrolysate completely replaced dietary protein. 3. Intravenous administration to four nephrotic children of 30 to 42 Gm. of casein hydrolysate daily during alternate weeks for four injection periods was not followed by consistent increases in the concentration of plasma amino acids or plasma proteins. No adverse effects were noted. 4. Reactions encountered were limited to flushing of the skin, a sensation of warmth, abdominal cramps, nausea, and vomiting. The latter two reactions could generally be completely avoided by reducing the rate of administration. 5. Some of the physiologic effects following intravenous administration of casein hydrolysate were discussed. 6. We recommend the intravenous administration of casein hydrolysate as the primary therapeutic procedure in the treatment of nephrotic crises particularly when complicated by bacteriemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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