The hydrogen bond proton donor properties of volatile halogenated hydrocarbons and ethers and their mode of action in anaesthesia
| Autor: | R. D. Bagnall, W. G. M. Jones, W. Bell, R. H. Davies |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Chemistry Hydrogen bond Condensed Matter Physics Medicinal chemistry Atomic and Molecular Physics and Optics Membrane medicine.anatomical_structure Membrane action Hydrocarbon Colligative properties medicine Phase model Organic chemistry Physical and Theoretical Chemistry Mode of action Sensitization |
| Zdroj: | International Journal of Quantum Chemistry. 10:171-185 |
| ISSN: | 1097-461X 0020-7608 |
| DOI: | 10.1002/qua.560100720 |
| Popis: | A phase model previously used for estimating the anaesthetic potencies of halogenated hydrocarbons is briefly reviewed, and a hydrogen bond proton donor scale for the set of compounds has been refined. Two further effects of these compounds are examined, their lethal and cardiac sensitization effects. Comparison of lethal and anaesthetic concentrations supports the view that the volume of the anaesthetic within the cell membrane is a critical determinant of anaesthetic action. Differences in the contributory effects of hydrogen bonding to the lethal, anaesthetic, and cardiac sensitization potencies are observed. The influence of the hydrogen bond proton donor interaction of a partially halogenated hydrocarbon is some 30% greater in its anaesthetic action than in its lethal effect. Comparison of the lethal and cardiac sensitization potencies indicates a similar component difference in the influence of hydrogen bonding but of opposite effect. It is suggested that in addition to the colligative effects of the compounds the difference in the hydrogen bonding components may represent a common process of membrane desensitization. The process is reviewed in relation to existing concepts of membrane action. |
| Databáze: | OpenAIRE |
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