Impact of high-throughput screening in biomedical research

Autor:	G. Sitta Sittampalam, Robert P. Hertzberg, William P. Janzen, Dragan A. Cirovic, Ricardo Macarron, David J. Burns, Tina Garyantes, Martyn Banks, Darren V. S. Green, Jeff W. Paslay, Dejan Bojanic, Ulrich Schopfer
Rok vydání:	2011
Předmět:	Pharmacology Risk analysis (engineering) business.industry Drug discovery Drug Discovery General Medicine Contributory factor business Productivity Pharmaceutical industry Biotechnology
Zdroj:	Nature Reviews Drug Discovery. 10:188-195
ISSN:	1474-1784 1474-1776
DOI:	10.1038/nrd3368
Popis:	High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1d0f5fd05d9f368f1dc535c4360ed993 https://doi.org/10.1038/nrd3368 Zobrazit plný text záznamu Plný text ve formátu PDF