Prediction of Parkinson’s disease severity based on RNFL thickness evaluated by OCT
| Autor: | Fj Ascaso, D. Pérez, Ja Cristobal, Jesús Ibáñez, J Lopez Del Val, B Jimenez Del Rio |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease genetic structures business.industry Nerve fiber layer Retinal General Medicine Neurological disorder medicine.disease eye diseases Surgery Ophthalmology chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Biomarker (medicine) Clinical severity sense organs Inverse correlation business Early onset |
| Zdroj: | Acta Ophthalmologica. 92 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.2014.t106.x |
| Popis: | Purpose To determine the relationship between peripapillary retinal nerve fiber layer (RNFL) thickness in Parkinson disease (PD) with the severity of this neurological disorder and to define a simple biomarker to predict clinical severity. Methods Peripapillary RNFL thickness was measured in 102 eyes from 52 PD patients by using optical coherence tomography (OCT) and compared with 97 eyes from 50 age-matched healthy controls. The Unified Parkinson's Disease Rating Scale (UPDRS) total score was used and responses in the ON medication state were measured. Results PD patients showed a statistically significant decrease in average peripapillary RNFL thickness compared with control eyes (p |
| Databáze: | OpenAIRE |
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