Potentielle Risiken von hochdosiertem Adrenalin zur Reanimation nach kurzzeitigem Herzstillstand im Tierversuch
| Autor: | U. Hörnchen, P. W. Berg, J. Schüttler |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cardiac output
medicine.medical_specialty Mean arterial pressure Resuscitation Dose business.industry Hemodynamics General Medicine Critical Care and Intensive Care Medicine medicine.disease Anesthesiology and Pain Medicine Epinephrine Internal medicine Ventricular fibrillation Circulatory system Emergency Medicine medicine Cardiology business medicine.drug |
| Zdroj: | AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie. 27:274-278 |
| ISSN: | 1439-1074 0939-2661 |
| DOI: | 10.1055/s-2007-1000296 |
| Popis: | We compared the haemodynamic effects of epinephrine 10 micrograms/kg iv (group A, n = 8) and 50 micrograms/kg iv (group B, n = 8) in a porcine CPR-model after 3 min of circulatory arrest induced by ventricular fibrillation. All animals of group A were successfully resuscitated after 4.9 +/- 2.8 min and 2.8 +/- 1.6 defibrillations, in group B only 6 of 8 animals were successfully resuscitated after 6.3 +/- 1.1 min and 4.0 +/- 2.7 defibrillations (Mean +/- SD). Cardiac output, left ventricular systolic pressure and mean arterial pressure during CPR were nearly identical in both groups. The first hour of restored spontaneous circulation in group B was characterised by a significantly increased heart rate combined with significantly lower values for cardiac inotropy, cardiac output, left ventricular systolic pressure and mean arterial pressure. It is concluded that in acute or short-term cardiac arrest the currently recommended epinephrine dosages are sufficient. Higher doses of epinephrine for CPR seem to be recommendable only after prolonged cardiac arrest and/or during prolonged resuscitation. |
| Databáze: | OpenAIRE |
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