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Aim: Relationship between virus titers of live Infectious Bursal disease (IBD) vaccines and their serum-conversion abilities was studied. Study design and Methodology: Five batches of each, of five IBD vaccine brands used in Nigeria, were tested for virus titers. Each of the vaccine brands was also used to vaccinate a group of fifteen 12-days old chicks to study their serum-conversion abilities. Mean antibody titers of the groups of chicks were plotted, on a graph, against virus titers of the vaccine brands used to vaccinate them. Results: Mean Modified Passive Haemagglutination titers of IBD virus in the vaccines,were:1,065.60±780.03,1,472.00±748.55,2,112.00±1984.00,2,176.00±1920. 00 and 2,585.00±926.92 while mean antibody titers they elicited were, 1,356.80±241.51, 1,280.00±174.88, 448.00±79.25, 998.40±196.27 and 332.80±51.20, respectively. Line of best fit of graph of antibody titers of vaccinated chicks on vaccine titers, showed that reducing titers of the live IBD vaccines improved their immunogenicity. Conclusions: The inverse relationship between virus titers of the vaccines and their Original Research Article British Journal of Medicine & Medical Research, 4(7): 1506-1513, 2014 1507 serum conversion abilities, suggests that, if viral titers of live IBD vaccines are too high, immune-suppression instead of enhancement of immune response may occur. |
