The Role ofde novoPurine Synthesis in Lymphocyte Transformation
| Autor: | R. W. E. Watts, A. C. Allison, A. D. B. Webster, T. Hovi |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Purine
0303 health sciences Purine nucleoside phosphorylase medicine.disease 3. Good health Adenosine deaminase deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biochemistry chemistry 030220 oncology & carcinogenesis medicine Cancer research Purine nucleoside phosphorylase deficiency Inosine Purine metabolism Nucleoside Nucleotide salvage 030304 developmental biology medicine.drug |
| Zdroj: | Ciba Foundation Symposium 48-Purine and Pyrimidine Metabolism ISBN: 9780470720301 Ciba Foundation Symposium 48 - Purine and Pyrimidine Metabolism |
| DOI: | 10.1002/9780470720301.ch13 |
| Popis: | Genetic defects in purine metabolism are associated with severe immunodeficiency. Adenosine deaminase deficiency impairs the function of both B- and T-lymphocytes whereas in purine nucleoside (inosine) phosphorylase deficiency there is more severe impairment of T-lymphocyte functions than of B-lymphocyte functions. The relative unimportance of the salvage pathway catalysed by hypoxanthine-guanine phosphoribosyltransferase is shown by the normal responses of T-lymphocytes from patients with the Lesch-Nyhan syndrome to antigenic and mitogenic stimulation. A mild deficiency of B-lymphocyte function is found in these patients. Agents inhibiting the de novo pathway of purine synthesis, including azaserine, 6-mercaptopurine and azathioprine in low doses, block the responses of normal human lymphocytes to mitogenic stimulation. These observations emphasize the importance of the de novo pathway of purine synthesis in lymphocyte responses to antigenic and mitogenic stimulation. There is considerable heterogeneity in the amount of labelled uridine incorporated into human and rat lymphocytes. This does not appear to reflect only a difference between T- and B-lymphocytes |
| Databáze: | OpenAIRE |
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