Novel PKC inhibitory analogs of balanol with replacement of the ester functionality
| Autor: | Steven E. Hall, G. Erik Jagdmann, Paul A. Gosnell, Hong Hu, Yen-Shi Lai, John A. Buben, Defauw Jean Marie, Heidi Crane |
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| Rok vydání: | 1995 |
| Předmět: |
Natural product
Stereochemistry fungi Organic Chemistry Clinical Biochemistry Pharmaceutical Science Metabolic stability Inhibitory postsynaptic potential Biochemistry Balanol chemistry.chemical_compound chemistry Drug Discovery Verticillium balanoides Molecular Medicine Moiety Protein kinase A Molecular Biology Protein kinase C |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 5:2015-2020 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(95)00344-s |
| Popis: | Balanol ((−)-1) is a potent protein kinase inhibitory natural product isolated from the fungus Verticillium balanoides . The presence of an ester functionality in this molecule has prompted concern over the metabolic stability of balanol, and has led to a search for active analogs lacking this moiety. The synthesis and serum stability for some of these is presented herein. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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