Poly-l-lactide Polymer-Based Triple Drug-Eluting Stent with Abciximab, Alpha-Lipoic Acid and Sirolimus in Porcine Coronary Restenosis Model
| Autor: | Bonsang Koo, Sang-Rae Lee, Jun-Kyu Park, Myung Ho Jeong, Min Young Lee, Dae Sung Park, Joong Sun Kim, Sun-Uk Kim, Jae-Woon Nah, Joo-Young Na, Young Joon Hong, Doo Sun Sim, Kyung Seob Lim, Han Byul Kim, Hyun Kuk Kim, Yeong Bae Jin, Sung Soo Kim, Jae Won Shim, Kang Jin Jeong, In-Ho Bae |
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| Rok vydání: | 2019 |
| Předmět: |
Neointimal hyperplasia
Bare-metal stent medicine.medical_specialty Materials science Polymers and Plastics General Chemical Engineering medicine.medical_treatment Organic Chemistry Urology Percutaneous coronary intervention Stent 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences 0104 chemical sciences Restenosis Drug-eluting stent Sirolimus Materials Chemistry medicine Abciximab 0210 nano-technology medicine.drug |
| Zdroj: | Macromolecular Research. 28:9-14 |
| ISSN: | 2092-7673 1598-5032 |
| DOI: | 10.1007/s13233-020-8004-5 |
| Popis: | This study evaluated the effect of a novel triple drug-eluting stent containing antithrombotic abciximab, antioxidative alpha-lipoic acid (ALA), and antiproliferative sirolimus in a porcine model. The coronary arteries of pigs were randomized into three groups: triple drug-eluting stent (TES; n=10), sirolimus-eluting stent (SES; n=10), and bare metal stent (BMS; n=10). At 28 days after stent implantation, a histopathologic analysis was performed. There were no significant differences in the injury score. There were significant differences in the neointimal area (2.3±0.6 mm2 in TES vs. 2.5±0.88 mm2 in SES vs. 3.3±0.58 mm2 in BMS, p |
| Databáze: | OpenAIRE |
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