Syntheses, biological evaluation of some novel substituted benzoic acid derivatives bearing hydrazone as linker

Autor:	Rajesh Sharma, Ganesh Prasad Mishra, Mukul R. Jain, Debdutta Bandyopadhyay
Rok vydání:	2021
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Chemistry In vivo Drug design Hydrazone General Chemistry Peroxisome Receptor Linker Combinatorial chemistry In vitro Benzoic acid
Zdroj:	Research on Chemical Intermediates. 47:5061-5078
ISSN:	1568-5675 0922-6168
Popis:	On the basis of rational drug design fourteen novel compounds having benzoic acid as acidic head, hydrazone as linker and substituted diaryl sulfanyl/aryl-cyclohexylsulfanyl as a hydrophobic tail were synthesized and characterized by physicochemical and spectrophotometric (FTIR, Mass, 1HNMR and 13CNMR) analysis. The spectral data were satisfactory with their structures. The designed compounds were docked against peroxisome proliferated activated receptors (PPARγ) and further evaluated for in vitro PPARγ agonist activity and in vivo hypoglycemic activity in wistar strain of albino rats. Compound 3k and 3m exhibited potent anti-diabetic activity without ulcerogenic toxicity and minimum side effects as weight gain. Therefore these compounds would be considered as promising agents for the development of novel antidiabetic agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1be6f45d9852b7303778534a18ba0677 https://doi.org/10.1007/s11164-021-04555-y Zobrazit plný text záznamu Plný text ve formátu PDF