Propranolol, Triamteren und Hydrochlorothiazid in fixer Kombination in der Hochdrucktherapie

Autor:	Hoenig B, Hiemstra S, Herrmann Jm
Rok vydání:	2008
Předmět:	medicine.medical_specialty Dose business.industry medicine.medical_treatment Diastole General Medicine Propranolol Essential hypertension medicine.disease Left ventricular hypertrophy Hydrochlorothiazide Internal medicine Heart rate medicine Cardiology Diuretic business medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 106:1138-1143
ISSN:	1439-4413 0012-0472
Popis:	The antihypertensive effect of propranolol, in fixed combinations with two dosages of triamteren and hydrochlorothiazide (Dociteren), was evaluated in a double-blind test on 19 patients with uncomplicated essential hypertension. No significant differences between the two dosages were found with respect to heart rate, as well as systolic and diastolic pressures on lying and standing up. Mean systolic and diastolic pressures were within the normotensive range with both dosages after four weeks. Increasing the diuretic component increased the type and frequency of side effects, without any additional therapeutic advantage. In seven of nine patients the previously present signs of left ventricular hypertrophy disappeared. In 9 patients the mean value of the Sokolow-Lyon index (RV5 + SV1) decreased from 4.078 mV before to 3.31 mV after an eight-week period of treatment. The results of various laboratory tests, except for a transient hyperuricaemia, did not change significantly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1bac28e31f169ab19e00dbd1a275afec https://doi.org/10.1055/s-2008-1070470 Zobrazit plný text záznamu