Survey of Current State of Off-label Drug Usage in Pediatrics and Pediatric Dosages

Autor:	Kamijo Takehiko, Asahi Mariko, Hirosawa Iori, Koike Ken'ichi, Oba Nobuhiro, Omori Shigeru
Rok vydání:	2005
Předmět:	Drug Pediatrics medicine.medical_specialty Dose business.industry media_common.quotation_subject Off-label use Drug usage Route of administration Pharmacotherapy medicine Dosing Medical prescription business media_common
Zdroj:	Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 31:179-185
ISSN:	1882-1499 1346-342X
DOI:	10.5649/jjphcs.31.179
Popis:	At present, the number of drugs approved for use in children is much less than that approved for adults, and the lack of drug information for pediatric pharmacotherapy is a problem. In this regard, both the quantity and quality of information in drug package inserts concerning use in children are often inadequate.In the present study, we retrospectively surveyed the approval status of drugs for pediatric use and dosing information for children using the database of Shinshu University Hospital. We did searches by patients' hospital numbers, dates of birth, drugs administered, date and route of administration, dosage and number of doses, etc. Also, the actual doses administered to patients were compared with the appropriate doses calculated for each patient and the applicability of formulae for calculating pediatric dosages in off-label use was examined. Approximately 60 % of prescription drugs were administered under off-label use. The dosage deviation ranges by Young' s age rule were statistically significant (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b7bbe7bf10eef7cad47cc7736fc0058 https://doi.org/10.5649/jjphcs.31.179 Zobrazit plný text záznamu