Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications

Autor:	Hisashi Suzuki, Yukie Yoshii, Emi Kaneko, Chika Igarashi, Kazunori Kawamura, Hiroki Matsumoto, Tatsuya Higashi, Hiroki Hashimoto, Ming-Rong Zhang
Rok vydání:	2019
Předmět:	Process development Health Toxicology and Mutagenesis Sodium Radiochemistry Public Health Environmental and Occupational Health chemistry.chemical_element 010403 inorganic & nuclear chemistry 01 natural sciences Pollution Polyvinylidene fluoride 0104 chemical sciences Analytical Chemistry Sulfone chemistry.chemical_compound Therapeutic index Nuclear Energy and Engineering chemistry In vivo Radiolysis Radiology Nuclear Medicine and imaging Cellulose Spectroscopy
Zdroj:	Journal of Radioanalytical and Nuclear Chemistry. 322:467-475
ISSN:	1588-2780 0236-5731
DOI:	10.1007/s10967-019-06738-9
Popis:	Hypoxia plays an important role in tumor prognosis. [64Cu]Cu-ATSM, a hypoxia-targeted radioactive agent, reportedly shows antitumor effect in vivo. For clinical application, [64Cu]Cu-ATSM must be manufactured at high concentrations to allow the administration of a therapeutic dose with safe intravenous bolus injection. Fifteen radical scavengers were tested to stabilize [64Cu]Cu-ATSM against radiolysis, and sodium l-ascorbate was selected. The optimal sterilization membrane filter was evaluated from polyvinylidene fluoride (PVDF), polyether sulfone, and mixed cellulose esters; PVDF showed the most efficient radiochemical yield after filtration. The proposed procedures can be used for the practical manufacturing of [64Cu]Cu-ATSM for therapeutic use.
Databáze:	OpenAIRE
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