ChemInform Abstract: Aza-Annulation of β-Enaminolactones: Application to the Synthesis of Enantiopure Difunctionalized Bicyclic Lactams

Autor:	Luc Dechoux, Catherine Kadouri-Puchot, Severine Hebbe, Valerie Toum, Jeanne Alladoum
Rok vydání:	2009
Předmět:	Annulation Lithium methoxide chemistry.chemical_compound Enantiopure drug Bicyclic molecule Chemistry Stereochemistry Molecule General Medicine Combinatorial chemistry
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200920146
Popis:	Diastereoselective aza-annulation of seven-membered β-enaminolactones 2 gives access to bicyclic heterocyles 5. Fragmentation of molecule 5a with lithium methoxide affords cis or trans bicyclic lactams 8 with excellent stereoselectivities.
Databáze:	OpenAIRE
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