Simple one-pot process for the bioresolution of tertiary amino ester protic ionic liquids using subtilisin

Autor:	Stephen J.C. Taylor, Jonathan Wiffen, Maude Brossat, Thomas S. Moody
Rok vydání:	2009
Předmět:	Chemistry Organic Chemistry Extraction (chemistry) Butyric anhydride Subtilisin One-Step Butyrate Catalysis Inorganic Chemistry Hexane chemistry.chemical_compound Ionic liquid Organic chemistry Physical and Theoretical Chemistry Selectivity
Zdroj:	Tetrahedron: Asymmetry. 20:2112-2116
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2009.09.007
Popis:	An efficient hydrolase-catalyzed bioresolution of tertiary amino ester protic ionic liquids has been demonstrated. Protic ionic liquids have been prepared in one step from the corresponding tertiary amino alcohols by treatment with butyric anhydride. After bioresolution, unreacted esters can be easily separated from the corresponding alcohols by extraction with hexane. Bioresolution of quinuclidin-3-yl butyrate has been performed with excellent selectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b12fad6bd4f344dc073f05d36b2d996 https://doi.org/10.1016/j.tetasy.2009.09.007 Zobrazit plný text záznamu Full Text from ScienceDirect