An Open-label Randomized Control Trial Comparing Clonidine and Buprenorphine for Medically-Assisted Opium Withdrawal of Adolescents
| Autor: | Shahab Lotfinia, Nour-Mohammad Bakhshani, Farnaz Sharifi Mood, Mahboubeh Firouzkouhi Moghadam, Alireza Noroozi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
education.field_of_study
business.industry Population 030508 substance abuse Medicine (miscellaneous) Opium law.invention Clonidine 03 medical and health sciences Psychiatry and Mental health Clinical Psychology 0302 clinical medicine Treatment demand Randomized controlled trial Opioid law Anesthesia medicine 030212 general & internal medicine Open label 0305 other medical science education business Buprenorphine medicine.drug |
| Zdroj: | International Journal of High Risk Behaviors and Addiction. 9 |
| ISSN: | 2251-872X 2251-8711 |
| DOI: | 10.5812/ijhrba.107160 |
| Popis: | Background: There is an increasing trend in treatment demand for opioid dependence among adolescents in Iran. However, evidence regarding effective treatment in this population is very limited. Objectives: This study aimed to compare the efficacy of clonidine and buprenorphine for inpatient medically-assisted withdrawal of adolescents with opioid dependence aged 12 and 16 years. Materials and Methods: The study is an open-label, randomized controlled trial with convenience sampling. In total, 36 adolescents took part in this study who were randomly assigned to buprenorphine or clonidine groups. The Clinical Opiate Withdrawal Scale was used to monitor the withdrawal severity on days one, two, three, seven, and 14. Results: The findings showed both treatments were effective. However, withdrawal symptoms in the buprenorphine group showed a greater reduction in the first seven days of withdrawal treatment. There was no significant difference in the length of hospitalization between the two groups. Patients with a longer duration of opioid use showed higher levels of withdrawal symptoms in the buprenorphine group on days one and three. Conclusions: Buprenorphine treatment was found to be more effective than clonidine in controlling opioid withdrawal during the initial days of treatment. However, it lost its superiority towards the end of the follow-up. It seems that clonidine could be a good alternative to buprenorphine in the medically-assisted withdrawal of adolescents with opioid dependence. |
| Databáze: | OpenAIRE |
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