Biochemical indices of liver function in malaria patients
| Autor: | Kazeem Sanjo Akinwande, Ayodele Ademola Adelakun, Isaac Oluwole Adediji, Babatunde Olaniyi Motayo |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology Bilirubin business.industry Significant difference Plasmodium falciparum medicine.disease biology.organism_classification Gastroenterology chemistry.chemical_compound Liver disease chemistry Liver enzyme Internal medicine parasitic diseases Immunology medicine Alkaline phosphatase Liver function business Malaria |
| Zdroj: | International Journal of Biomedical Research. 6:177 |
| ISSN: | 0976-9633 |
| DOI: | 10.7439/ijbr.v6i3.1536 |
| Popis: | Introduction:Malaria is a tropical disease, which has hepatocellular involvement and is a significant cause of morbidity and mortality especially among children. Objective: This study investigated the biochemical indices of liver function in children with malaria and compared their results with healthy children (age and sex-matched). Methodology: Fifty patients (age: 5.1 ± 1.9 years) were enrolled from the Pediatrics’ clinic of a tertiary health institution in Ogun state, Nigeria. Fifty age- and sex- matched apparently healthy children, from the same geographical location were selected as controls. A thick film microscopy was used to confirm the presence of Plasmodium falciparum trophozoite in patients and its absence in controls. The in vitro determinations of the plasma activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), plasma total and conjugated bilirubin were performed using standard methods. Data obtained were statistically analyzed using student’s t-test and P |
| Databáze: | OpenAIRE |
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